Leaky gut syndrome supplements

Leaky gut syndrome is a serious condition that affects the intestinal tract. Generally, the leaky gut syndrome is characterized by the permeation of toxins and bad bacteria into your blood. This increased permeability can be detrimental to human health and has also been linked to certain autoimmune conditions, chronic inflammation and skin problems.

The interior lining of the intestines is like a powerful filter that separates substances that pass through it. If a foreign substance passes, it can cause damage to the entire body. In a healthy gut, the intestines are resistant or impermeable to things that can be harmful to the body.

Some people may have the leaky gut syndrome, which is a frustrating condition. However, there are many supplements, as well as other health-related options that may help relieve symptoms of this condition.

The medical community is still debating whether the leaky gut syndrome is real or not.

Recent studies[1] are now revealing that leaky gut syndrome is definitely real and also not to be ignored. If you suspect that you have it, it’s important to seek a diagnosis from a physician soon.

The following are three tests that your doctor may perform to determine if you have leaky gut syndrome:

  • IgG food antibodies (food sensitivities) test 
  • IgG intestinal permeability (lactulose mannitol) assessment
  • Test for zonulin

The level of lactulose and mannitol (two indigestible sugars) in your urine is measured by the intestinal permeability test. Should these sugars be found, it can only mean the intestinal gut has been breached.

The IgG food antibodies test can detect different foods that cause an allergic reaction and an allergy reaction. A leaky gut is indicated by several food antibodies.

The ZFP test determines if ZFP is at a level in the body that can disrupt intestinal tight junctions.

Also read: 8 foods that are healthy for the pancreas

Leaky gut syndrome symptoms

The stomach is a part of the digestive tract. The gastrointestinal (GI) system serves to digest and process food, providing nutrients that get absorbed into our bloodstream. When there is an intestinal barrier breach, it may allow harmful bacteria or toxins in your body without any warning signs- leaky gut syndrome. Frequent symptoms can include the following:

  • Bloating
  • Abdominal pain/cramps/pressure with bowel movements
  • Excessive gas or belching
  • Chronic constipation
  • Diarrhea alternating with normal stools
  • Frequent loose stool accidents that make clothing wet.

These symptoms can be caused by a variety of other illnesses. If you have any of these symptoms, talk to your doctor. Your doctor may want to run additional tests.

How to heal leaky gut

Supplements to help leaky gut syndrome

The list below is of supplements that have all shown promising research and studies in regard to their effectiveness as a treatment for the leaky gut syndrome.


Curcumin is a viable natural substance found in many familiar spices from around the world. It is primarily responsible for the bright yellow color of many commonly used spices which include turmeric.

Curcumin, no matter how much you take or what mode of administration, will have poor bioavailability. However, research has shown that when curcumin is absorbed into the body, it tends to focus more on the gastrointestinal tract[2]. One of curcumin’s properties is that it fights inflammation, which explains why it benefits the lining of the digestive tract.


Zinc is an essential nutrient for the development of new tissues, they help with tissue repair, protein synthesis and the immune system. It also helps keep skin looking healthy and assists in maintaining a strong hair follicle. One surprising role it plays is helping people with leaky gut.

In 2001, a study that focused on patients with Crohn’s disease found that zinc supplementation strengthened the gut lining significantly[3]. 

Fiber and butyrate

Dietary fiber is a staple in the diet of most healthy people. Just like probiotics, fiber helps to improve the microbiome by helping food move more easily through the intestines and making you feel healthier and more energized.

Fiber fermentation helps to promote butyrate production which is a short-chain amino acid. Mucin is produced and the GI tract is tightened.

Collagen peptides

Collagen is a type of protein that your body needs to stay healthy. It can be found in almost every tissue of the body with many different benefits including strengthening hair, skin, nails and bones as well as repairing damaged tissues and joints, it even plays a role in gut health. 

Collagen Peptides can help improve intestinal health. A recent study shows that collagen peptides aid in protecting the lining of your digestive tract from leakage[4].

Supplements to heal leaky gut


Probiotics are known to be extremely effective in the treatment and management of a range of medical conditions, which doctors and pharmacists alike refer to. Probiotics have a range of positive effects on the digestive system if taken on a daily basis and these healthy microbes can help not just with gastrointestinal but many other related health issues.

In a 2012 study done by researchers, it was found that probiotics help to reduce zonulin, which is often a sign of an abnormally permeable intestinal tract[5].

Vitamin D

Just as it is important to drink enough water on a daily basis, you want to make sure that you are getting enough vitamin D per day too. Vitamin D isn’t well known for its health benefits but very essential in maintaining immune system balance in the gut and preventing gut health problems.

Vitamin D deficiency can lead to poor immune function, frequent infections and an overgrowth of harmful bacteria in the gut, which can result in major maladies including inflammatory bowel disease and even irritable bowel syndrome, but because Vitamin D also helps to maintain a strong protective barrier around our bodies; consuming it through diet or supplementation is an effective way to ward off problems associated with leaky gut.


Glutamine is a naturally-occurring substance that your body produces to aid in healing and repairing the fragile intestinal lining. Glutamine aids in the protection of the gut’s tight junction barrier system, helping to ensure that harmful substances do not enter your bloodstream which may create inflammation.

L-glutamine is another amazing supplement that can be taken by those who have the leaky gut syndrome, along with many other conditions. It’s a supplement that plays an important role in the repair of the intestinal lining and has been shown to reduce intestinal permeability.

Although some studies have not been able to prove the effectiveness of L-glutamine in the fight against leaky gut, a meta-analysis has shown that it promotes gut barrier function and reduces damaging markers related to leaky gut.

Other leaky gut cure supplements

In addition to the top supplements already discussed, there are other supplements that can help repair intestinal permeability or support the healing of the gut lining. Here is a summary of a few more of those supplements.

Fish and Fish Oil

Fish oil is a supplement that people often look to when wanting to keep their hearts healthy or as a natural alternative to other oils. Omega-3 fatty acids present in this type of supplement are essential to maintaining a healthy cholesterol balance and may also relieve joint pain, skin irritations, ulcers, and can help with brain function.

Eating wild fish or taking a fish oil supplement may help you keep your gut sealed.

Vitamin A

Vitamin A was found in a study to induce changes in gut barrier function[6]. Vitamin A deficiency increased intestinal permeability while restoring levels decreased it, suggesting that the vitamin has an impact on intestinal permeability. This study supports the idea that taking Vitamin A supplements could help heal leaky gut syndrome.


Quercetin is an anti-inflammatory compound from plants that help restore the gut lining. It helps to relieve the symptoms of inflammatory bowel disease, and can also aid in weight loss when taken as a supplement with other supplements such as L-glutamine.

Digestive enzymes

Digestive enzymes help break down food for digestion, which can reduce leaky gut symptoms. They also make sure that proteins, fats and carbohydrates are fully broken up during the digestive process to prevent wear and tear on your system.

Bacterial toxins, like undigested food particles, may enter the body through your gut wall and cause systemic inflammation if they are mistaken by your body for a foreign invader.

There are different formulas available to help your body digest proteins, carbohydrates and fats. The main compounds of these formulas include amylase, protease, and lipase. A basic formula will include these compounds in appropriate quantities to give the optimal results.


Immunoglobulin cells are a type of immune cells that serve as the body’s first-line defense against bacteria and antigens. They typically bind to allergic triggers or bacterial toxins in your gut lining.

One of the main causes behind leaky gut symptoms is bacterial inflammation. However, immunoglobulin G binds and expels potential irritants from your body to avoid further problems.

Research has shown that IBS patients who did not respond to other treatments, like diet and so on, are helped by supplemental immunoglobulins[7].


Although all of these supplements can be helpful in healing leaky gut, you do not necessarily have to use them all.

Rather than trying to take many supplements and experimenting with an endless list of options, we recommend focusing on the top three: Probiotics, L-glutamine, and vitamin D.

And never forget: Eating a diet high in healthy fats and stress-reduced daily habits with a good sleep schedule matters just as much as taking supplements.

Also read: HGH gut/bubble gut – causes, treatment


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